Mild Conditions for Copper-Catalyzed N-Arylation of Imidazoles
نویسندگان
چکیده
منابع مشابه
Copper-catalyzed oxidative arylation of heteroarenes under mild conditions using dioxygen as the sole oxidant.
Arylation of heteroarene has been intensively studied over the past few years because aryl-substituted aromatic heterocycles are known to exhibit interesting biological activities and are also useful as electronic materials. Numerous methods have been reported to successfully construct this motif by transition-metal-catalyzed cross-coupling and most of them required expensive transition-metal c...
متن کاملMechanistic studies on the copper-catalyzed N-arylation of amides.
The copper-catalyzed N-arylation of amides, i.e., the Goldberg reaction, is an efficient method for the construction of products relevant to both industry and academic settings. Herein, we present mechanistic details concerning the catalytic and stoichiometric N-arylation of amides. In the context of the catalytic reaction, our findings reveal the importance of chelating diamine ligands in cont...
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Copper(II)-catalyzed boronic acid promoted C-N bond cross-coupling reactions have been successfully developed for sequential N-arylation of C-amino-NH-azoles. These general protocols are compatible with a variety of aryl/hetero-aryl boronic acids and provided rapid access to a diverse array of diarylaminoazole derivatives in a two-step sequence or in one-pot.
متن کاملCopper-catalyzed arylation of 1H-perfluoroalkanes.
A general method has been developed for arylation of readily available 1H-perfluoroalkanes. The method employs aryl iodide and 1H-perfluoroalkane reagents, DMPU solvent, TMP(2)Zn base, and a copper chloride/phenanthroline catalyst. Preliminary mechanistic studies are reported.
متن کاملCopper-catalyzed N-arylation of amides using (S)-N-methylpyrrolidine-2-carboxylate as the ligand.
(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.
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ژورنال
عنوان ژورنال: Synthesis
سال: 2011
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-0030-1260144